The F2000R is notably seen used by Misaka 9982 and Misaka 10031, while Misaka 10032 does not bring her rifle to her own experiment, instead opting to use only her esper powers. The F2000R's targeting suite is usually linked to the Sister's signature Electron Goggles via a cable that plugs into what would be the scope's rear lens on a standard F2000, which, among expected accuracy and ease-of-use benefits, allows tactics like firing around corners. While externally identical, the F2000R's scope housing is actually home to an onboard electronic fire control suite which has features like infrared target detection, target movement prediction, and wind compensation.
As the F2000R is said to be rather quiet (comparable to cheap firecrackers) it can be assumed the custom muzzle device also dampens sound, although not nearly to the degree a true suppressor would.
The F2000R visually differs from a standard F2000 with its custom-made section added to the muzzle, which both serves as a flash hider and makes the rifle and launcher's forms blend together better, making it look more like one single weapon. The standard issue weapon for the Sisters are modified FN F2000s fitted with FN GL-1 grenade launchers, designated F2000R in-universe the rifle is nicknamed the Toy Soldier due to its (polymer, futuristic) appearance. He opens fire, hitting a smoke detector and setting off the fire alarm.